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Pat Venditte is a good example of what the future might hold. He's not genetically or chemically enhanced; Venditte is a naturally born ambidextrous switch pitcher who plays for Creighton University in the NCAA. He can switch from being a right or left handed pitcher at a moment's notice. This is advantageous for the same reason that switch hitters alter their batting stances (a skill that does not require ambidexterity, also known as cross-dominance).
I can see cross-dominance being an accepted feature of the enhanced human. Maintaining physical asymmetry doesn't make a lot of sense -- handedness is a throwback to our evolutionary history and most likely has a genetic basis (although the exact reason for handedness is still an unsolved mystery in biology).
At the same time, the advantages of being ambidextrous are self-evident and numerous. Jimi Hendrix, for example, was ambidextrous and he had perfect pitch (talk about winning the genetic lottery!!). Some good examples of cross-dominance in sports can be found here.
Including the ability to throw a curve that lands low and inside against a tough left-handed hitter.
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